2020

Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions

Noriaki Yoshida, Kay Shigemori, Nicholas Donaldson, Nicolas Andrew Coredero, Kristen Stevenson, Xia Bu, Fumiko Arakawa, Mai Takeuchi, Kouichi Ohshima, Akjnori Yoda, Samuel Y. Ng, David M. Weinstock “Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions”. Blood. 2019001815. January 21, 2020.

Breaking Down The Barriers to Define and Treat NK/T Cell Lymphoma

Bethany Mundy-Bosse & David M. Weinstock “Breaking Down The Barriers to Define and Treat NK/T Cell Lymphoma". Cancer Cell. March 16, 2020.

AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells 

Cidado J, Boiko S, Proia T, Ferguson D, Criscione SW, San Martin M, Pop-Damkov P, Su N, Roamio Franklin VN, Sekhar Reddy Chilamakuri C, D'Santos CS, Shao W, Saeh JC, Koch R, Weinstock DM, Zinda M, Fawell SE, Drew L.Clin Cancer Res. 2020 Feb 15;26(4):922-934. doi: 10.1158/1078-0432.CCR-19-1853. Epub 2019 Nov 7.PMID: 31699827

Targeting EZH2 for the Treatment of Hepatosplenic T-cell Lymphoma

Pikman Y, Conway AS, Robichaud AL, Kitara S, Church AJ, Kennedy AL, Silverman LB, Billett AL, Weinstock DM, Harris MH, Stegmaier K.Blood Adv. 2020 Apr 14;4(7):1265-1269. doi: 10.1182/bloodadvances.2019001256.PMID: 32232478 

Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

Bararia D, Hildebrand JA, Stolz S, Haebe S, Alig S, Trevisani CP, Osorio-Barrios F, Bartoschek MD, Mentz M, Pastore A, Gaitzsch E, Heide M, Jurinovic V, Rautter K, Gunawardana J, Sabdia MB, Szczepanowski M, Richter J, Klapper W, Louissaint A Jr, Ludwig C, Bultmann S, Leonhardt H, Eustermann S, Hopfner KP, Hiddemann W, von Bergwelt-Baildon M, Steidl C, Kridel R, Tobin JWD, Gandhi MK, Weinstock DM, Schmidt-Supprian M, Sárosi MB, Rudelius M, Passerini V, Mautner J, Weigert O.Cell Rep. 2020 Apr 22:107522. doi: 10.1016/j.celrep.2020.107522. 

DT2216-a BcL-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

Yonghan He, Raphael Koch, Vivekanada Budgamunta, Peiyi Zhang, Xuan Zhang, Sajid Khan, Dinesh Thummuri, Yuma T. Ortiz, Xin Zhang, Dongwen Lv, Janet S., Wiegand, Wen, Adam C. Palmer, Guangrong Zheng, David M. Weinstock, and Daohong Zhou. 2020. Journal of Hemotology. 13:95 https://doi.org/10.1186/s13045-020-00928-9

Signaling input from divergent pathways subverts B cell transformation

Lai N.Chan, Mark A. Marrakami, Mark E. Robinson, Rebecca Caeser, Teresa Sadras, Jaewoong Lee, Kadriye Nehir Cosgun, Kohei Kume, Vishal Khairnar, Gong Xiao, Mohamed A. Ahmed, Eamon Aghania, Gauri Deb, Christian Hurtz, Seyedmehdi Shojaee, Chao Hong, Petri Polonen, Matthew A, Nix, Zhengshan Chen, Chun Wei Chen, Jianjun Chen, Andreas Vogt, Merja Heinaniemi, Olli Lohi, Arun P. Wiita, Shai Izraeli, Huimin Geng, David M. Weinstock, & Markus MMuschen 2020. Nature.